3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid analogues and treatment of cerebral edema therewith
US4916147A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 1986 |
| Grant date | Apr 10, 1990 |
| Priority date | — |
| Expiry date | Jun 21, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds of the general formula: ##STR1## [wherein X represents an oxygen atom or sulfur atom, R.sup.1, R.sup.2 and R.sup.3 represent a hydrogen atom, a halogen atom or an alkyl group of from 1 to 4 carbon atom(s) independently or a formula: R.sup.3' ##STR2## (wherein R.sup.3' represents a hydrogen atom or an alkyl group of from 1 to 4 carbon(s)) in place of a formula: ##STR3## R.sup.4 represents a general formula: ##STR4## or --N(R.sup.9).sub.2 (in which W represents an oxygen atom or sulfur atom, R.sup.6, R.sup.7 and R.sup.8 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group of from 1 to 4 carbon atom(s), a hydroxy group or an alkoxy group of from 1 to 4 carbon atom(s) independently, each of R.sup.9 represents a hydrogen atom, an alkyl group of from 1 to 4 carbon atom(s) or a phenyl group and Y represents a single bond or an alkylene group or an alkenylene group of from 1 to 4 carbon atom(s).), and R.sup.5 represents a 5-tetrazolyl group or a general formula: --COOR.sup.10 (in which R.sup.10 represents a hydrogen atom or an alkyl group of from 1 to 4 carbon atom(s))] and non-toxic salts possess inhibitory effect on cerebral edema.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.