Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides
US4916149A · kind A · utility
4Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1988 |
| Grant date | Apr 10, 1990 |
| Priority date | — |
| Expiry date | Dec 29, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D235/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds of the general formula ##STR1## wherein R is hydrogen atom or a trifluoromethyl, carboxy, C.sub.2-5 alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C.sub.1-4 alkylsulfonyl group; PA0 R.sup.1 is hydrogen atom or a linear or branched chain C.sub.1-4 alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfonyl, benzylthio, benzylsulfonyl, phenyl, hydroxy or mercapto group; and PA0 R.sup.2 is hydrogen or chlorine atom, as well as their pharmaceutically acceptable salts. The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/K ratio.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.