Paramagnetic chelates useful for NMR imaging

US4916246A · kind A · utility

Assignee

• Bracco Chimica S.p.A. · IT

Inventors

• Ernst Felder · Lugano, CH
• Fulvio Uggeri · Codogno, IT
• Luciano Fumagalli · Milano, IT
• Giorgio Vittadini · Milano, IT

Key dates

• Filing date: Jan 12, 1987
• Grant date: Apr 10, 1990
• Expiry date: Jan 12, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds suitable for NMR imaging having the formula: ##STR1## wherein a is 2 or 3; PA0 b is an integer from 0 to 4; PA0 Me.sup.(a+) is Fe.sup.(2+), Fe.sup.(3+), Gd.sup.(3+), or Mn.sup.(2+) ; PA0 E.sup.(b+) is an ion of an alkali metal, alkaline earth metal, alkyl ammonium, alkanol ammonium, polyhydroxyalkyl ammonium, or basic protonated amino acid, said ions representing a total charge of b; PA0 m is an integer from 1 to 5; PA0 R is H, alkyl with from 1 to 8 carbon atoms, alkyl with from 1 to 8 carbon atoms wherein from 1 to 5 carbons are substituted with OH; aralkyl with 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, hydroxyl, carboxyl, carboxamide, ester, SO.sub.3 H, sulfonamide, lower alkyl, lower hydroxy alkyl, amino, acylamino; (poly)oxa-alkyl with 1 to 50 oxygen atoms and from 3 to 150 carbon atoms, wherein 1 to 5 hydrogen atoms may be substituted by OH; PA0 R.sub.1 is the same as R.sub.2 or PA1 is --CH.sub.2 COOZ, --CH(CH.sub.3)COOZ, CH.sub.2 CH.sub.2 --N(CH.sub.2 COOZ).sub.2, a hydroxy arylalkyl, hydroxy pyridylalkyl, hydroxy aryl(carboxy)alkyl or hydroxy pyridyl-(carboxy)alkyl radical, where the aryl or pyridyl radical may be substituted by hydro…