Carboxamide derivatives of indoles and leucotriene antagonizing use thereof
US4918094A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 16, 1986 |
| Grant date | Apr 17, 1990 |
| Priority date | — |
| Expiry date | Oct 16, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides a series of novel heterocyclic amides of formula I in which the group >X-Y-Z< is selected from >C.dbd.CH--N<, >C.dbd.N--N<, >N--(CH.sub.2)--N<, >CH--CH.sub.2 --N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds: pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.