2',6'-Dideoxy derivatives of anthracycline glycosides
US4918173A · kind A · utility
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2References
5Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 30, 1986 |
| Grant date | Apr 17, 1990 |
| Priority date | — |
| Expiry date | Jun 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to new tetralins and their use for the preparation of anthracyclinones and anthracyclins. These tetralins contain at least one chiral carbon atom and correspond to the formula (V) below: ##STR1## in which: R.sub.1 and R.sub.2 denote a hydrogen atom, or a halogen atom or the group OCH.sub.3, provided that one of the two substituents (R.sub.1 or R.sub.2) must denote OCH.sub.3, and PA1 R.sub.3 denotes a hydrogen atom or the OR' group, R' being hydrogen or a hydroxyl-protecting group. Application: synthesis of glycosides of great therapeutic value.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.