Process for recimization of an optically active alpha-amino acid amides and process for producing optically active alpha-amino acids
US4918196A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1986 |
| Grant date | Apr 17, 1990 |
| Priority date | — |
| Expiry date | Feb 21, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for optically isomerizing an optically active alpha-amino acid amide comprising heating a D-alpha-amino acid amide or an L-alpha-amino acid amide in the presence of a strongly basic compound; and a process for producing an L-alpha-amino acid, which comprises PA1 (1) subjecting a D,L-alpha-amino acid amide or a mixture of a major amount of a D-alpha-amino acid amide and a minor amount of an L-alpha-amino acid amide to the action of a microorganism having the ability to hydrolyze the L-alpha-amino acid to obtain a hydrolyzate containing the L-alpha-amino acid and D-alpha-amino acid, PA1 (2) separating the L-alpha-amino acid from the hydrolyzate and recovering the remaining D-alpha-amino acid amide. PA1 (3) heating all or part of the recovered D-alpha-amino acid amide in the presence of a strongly basic substance to obtain a D,L-alpha-amino acid amide or a mixture of a major amount of the D-alpha-amino acid amide and a minor amount of the L-alpha-amino acid amide, and PA1 (4) recycling the D,L-alpha-amino acid amide or the mixture to step (1) as part or all of the starting material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.