Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates
US4920216A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 28, 1987 |
| Grant date | Apr 24, 1990 |
| Priority date | — |
| Expiry date | May 28, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J75/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention concerns a method of substituting a chlorine atom for a predetermined hydrogen atom located within an organic compound which comprises contacting the organic compound containing the predetermined hydrogen atom with an esterifying agent comprising a pyridine ring or a substituted or fused ring derivative of a pyridine ring so as to produce an ester and treating the ester with a chlorinating agent so as to substitute the chlorine atom for the predetermined hydrogen atom. The ester comprises the pyridine ring or the substituted or fused ring derivative of the pyridine ring so positioned within the ester with respect to the predetermined hydrogen atom that a chlorine atom attached to the nitrogen atom of the pyridine ring or substituted or fused ring derivative of the pyridine ring reacts with the predetermined hydrogen atom. Another aspect of the invention is a method for converting a predetermined single bond between a carbon atom and another atom in an organic compound into a double bond between the carbon atom and the other atom which comprises substituting a chlorine atom for a predetermined hydrogen atom bound to the carbon atom or the other atom of the organic com…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.