Method of enhancing the biodistribution of antibody for localization in lesions
US4921690A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1988 |
| Grant date | May 1, 1990 |
| Priority date | — |
| Expiry date | Apr 12, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for enhancing the biodistribution of antibody for localization in lesions comprising initially exposing a mammalian subject containing lesion-associated marker substance to a first antibody specific for a given epitope of the marker substance, and after a period of time such that the marker substance has associated with the antibody, exposing the mammal to a further amount of the same antibody, or a second antibody specific either for an epitope of the marker substance different from the epitope for which the first antibody is specific, or for the same epitope of the marker substance as the first antibody but of a different binding affinity from the first antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.