Erythromycin a 11,12-carbonate 9-oxime derivatives
US4921839A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 22, 1988 |
| Grant date | May 1, 1990 |
| Priority date | — |
| Expiry date | Feb 22, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antibacterially active 11,12-carbonate derivatives of erythromycin 9-(optionally substituted)oxime and 9-imino compounds and their pharmaceutically acceptable ester or acid addition salt thereof: ##STR1## wherein R.sup.1 denotes an oxime group, a substituted oxime group, or an imino group; PA0 R.sup.3 denotes a hydrogen atom or an unsubstituted or substituted alkyl group; PA0 R.sup.7 denotes hydrogen or methyl; PA0 one of R.sup.8 and R.sup.9 denotes hydrogen, hydroxy, alkoxy, alkanoyloxy, amino, substituted amino, or a group of the formula R.sup.A --SO.sub.2 --O--, in which R.sup.A denotes an organic group, and the other of R.sup.8 and R.sup.9 denotes hydrogen, or PA0 R.sup.8 and R.sup.9 together denote an oxo group, an oxime group, or a substituted oxime group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.