Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
US4921854A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 22, 1987 |
| Grant date | May 1, 1990 |
| Priority date | — |
| Expiry date | Dec 22, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The compounds of the general formula I ##STR1## and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I PA0 A stands for --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 CH.sub.2 --or --CH.dbd.CH--; PA0 R.sub.4 is hydrogen, C.sub.1-4 alkyl or optionally substituted phenyl; PA0 r is 0, 1, 2, 3 or 4; PA0 R.sub.1 stands for hydrogen of C.sub.1-5 alkanoyl; PA0 R.sub.2 represents hydrogen, C.sub.1-5 alkanoyl or a group of the general formula (a) ##STR2## wherein R stands for hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, phenyl or phenyl-C.sub.1-3 alkyl and PA0 R.sub.3 stands for hydrogen. The compounds of the general Formula I can be prepared by reacting a 2-mercapto-4,6-diamino-pyrimidine of the general Formula II ##STR3## with a dihalo compound of the general Formula III ##STR4## (wherein Y and Z are halogen).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.