Process for the synthesis of 1-substituted imidazole-5-carboxylic acids and carboxylic acid derivatives
US4921955A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 18, 1987 |
| Grant date | May 1, 1990 |
| Priority date | — |
| Expiry date | Dec 18, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of 1,5-disubstituted imidazoles of the formula ##STR1## by alkylation of an N-cyanoformamidine of the formula II EQU X--NH--CH.dbd.N--CH (II) to form an N,N-disubstituted N'-cyanoformamidine of the formula ##STR2## which is cyclised under the action of bases to form a 4-aminoimidazole of the formula ##STR3## and then reduced to form the product of the formula I. The invention relates also to a special process for the reduction of the aminoimidazole V to I, and to intermediate compounds for carrying out this process and to processes for the preparation of the intermediate compounds. The meaning of the substituents X and L is explained in detail in the text.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.