Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, processes for their preparation and their use as medicaments

US4921998A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Niewohner · Wermelskirchen, DE
• Franz-Peter Hoever · Cologne, DE
• Bodo Junge · Wuppertal, DE
• Elisabeth Perzborn · Wuppertal, DE
• Friedel Seuter
• Volker-Bernd Fiedler · Leverkusen, DE

Key dates

• Filing date: May 15, 1989
• Grant date: May 1, 1990
• Expiry date: May 15, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/82
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substrituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, and PA0 R.sup.5 and R.sup.6 each independently is hydrogen or alkyl, or PA0 one of the radicals R.sup.5 or R.sup.6 is benzyl, and physiologically acceptable salts thereof with mono- and divalent cations.