Arg-Serpin human plasminogen activator inhibitor designated PAI-2
US4923807A · kind A · utility
19Cited by
1References
13Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Feb 6, 1987 |
| Grant date | May 8, 1990 |
| Priority date | — |
| Expiry date | Feb 6, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to an Arg-Serpin human plasminogen activator inhibitor designated PAI-2. This protein is prepared via recombinant DNA means. The invention also includes other serpins which can be made by amino acid substitutions or deletions in conserved regions of PAI-1 and PAI-2, as shown in FIG. 4. The proteins of the invention can be used to inhibit, or at least modulate, human plasminogen activator activity in a variety of physiological conditions, e.g., fibrinolysis, tumor metastasis, and tumor growth.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.