Substituted 1-(1H-imidazol-4-yl)alkyl-benzamides as anti-ischemics and as alpha-2-adrenergic receptor agonists
US4923865A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 6, 1989 |
| Grant date | May 8, 1990 |
| Priority date | — |
| Expiry date | Apr 6, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New substituted 1-(1H-imidazol-4-yl)alkyl-benzamides and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula ##STR1## wherein R.sub.1, R.sub.2 =hydrogen or C.sub.1 -C.sub.4 -alkyl, PA1 R.sub.3 =hydrogen, amino, hydroxyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl, PA1 R.sub.4 =hydrogen or C.sub.1 -C.sub.4 -alkyl, or PA1 R.sub.3 R.sub.4 N=pyrrolidino, piperidino or morpholino, PA1 R.sub.5 and R.sub.6 =hydrogen, hydroxyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, at least one of PA1 R.sub.5 and R.sub.6 being other than hydrogen. These compounds are prepared either by reacting a nitrogen compound with an alkyl 1-(1H-imidazol-4-yl)alkyl-benzoate or with a 1-(1H-imidazol-4-yl)alkyl-benzoic acid, or by hydrolyzing in an acid medium a 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzonitrile. The compounds have anti-ischemic and .alpha..sub.2 -adrenoceptor agonist activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.