1,2-diamino compounds, process for their preparation and pharmaceutical compositions containing them

US4923889A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Herbert Leinert · Heppenheim, DE
• Christos Tsaklakidis · Weinheim, DE
• Gisbert Sponer · Hemsbach, DE

Key dates

• Filing date: Aug 11, 1988
• Grant date: May 8, 1990
• Expiry date: Aug 11, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are disclosed, including 2-diethylamino-3-isobutoxy-N-phenyl-N-2-furanyl-methyl-propylamine and compounds of the formula: ##STR1## wherein R.sub.1 is an iso-C.sub.4 -C.sub.6 -alkyl radical; A is a valency bond or a straight-chained or branched alkyl radical containing up to 6 carbon atoms; R.sub.4 is a phenyl radical which is unsubstituted or substituted one or more times by C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.1 -C.sub.3 -alkoxy, C.sub.2 -C.sub.6 -alkenyloxy, hydroxy-C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkylenedioxy, hydroxy-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.6 -alkylamino, di(C.sub.1 -C.sub.6 -alkyl)amino, C.sub.1 -C.sub.3 -alkoxycarbonyl-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphinyl, C.sub.1 -C.sub.6 -alkylsulphonyl, C.sub.1 -C.sub.6 -alkylsulphonyloxy, carboxyl, C.sub.1 -C.sub.3 -alkoxycarbonyl, aminocarbonyl, mono- or di(C.sub.1 -C.sub.6 -alkyl)aminocarbonyl, halo-C.sub.1 -C.sub.6 -alkyl, cyano, or halogen; and R.sub.5 is a benzyl radical substituted at least once by C.sub.1 -C.sub.3 -alkoxy. The compounds are useful for the treatment of hear…