Leukotriene LTD.sub.4 and LTB.sub.4 antagonists
US4923891A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 1988 |
| Grant date | May 8, 1990 |
| Priority date | — |
| Expiry date | Sep 9, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D339/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention encompasses compounds of Formula I ##STR1## and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: PA1 X, Y, and Z are each independently O or S with S optionally oxidized to S=O; PA1 Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6 carbon atoms; PA1 R.sub.1 is hydrogen or lower alkyl; PA1 n is 0 to 5; PA1 R.sub.2 is hydrogen, lower alkyl, cycloalkyl, --(CH.sub.2).sub.n --CO.sub.2 R.sub.1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; and PA1 Ar is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl. This invention is in the field of pharmaceutical agents which act as leukotriene D.sub.4 (LTD.sub.4) antagonists and includes embodiments which act as leukotriene B.sub.4 (LTD.sub.4) antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.