Derivatives of physiologically active substance K-252
US4923986A · kind A · utility
87Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1988 |
| Grant date | May 8, 1990 |
| Priority date | — |
| Expiry date | Nov 8, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-ep oxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W.sub.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y represent various substituents. The compounds are physiologically active substances that inhibit protein kinase C and exhibit an antitumor activity, and are useful as medicines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.