Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III

US4924012A · kind A · utility

Assignee

• Rhone-Poulenc Sante · FR

Inventors

• Michel Colin · Colomiers, FR
• Daniel Guenard · Montrouge, FR
• Francoise Gueritte-Voegelein · Les Ulis, FR
• Pierre Potier · Paris, FR

Key dates

• Filing date: Apr 3, 1989
• Grant date: May 8, 1990
• Expiry date: Apr 3, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-deacetylbaccatine III of general formula (III), R.sub.1, R.sub.2 and R.sub.3 denoting hydroxy-protecting groups, followed by the replacement of the protecting groups by hydrogen. ##STR1##