Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4925677A · kind A · utility
193Cited by
5References
31Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 31, 1988 |
| Grant date | May 15, 1990 |
| Priority date | — |
| Expiry date | Aug 31, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/205
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A biodegradable hydrogen matrix is provided, useful for the controlled release of pharmacologically active agents. The matrix is formed by cross-linking a proteinaceous component and a polysaccharide or mucopolysaccharide, and then loading a selected drug therein. By varying temperature, ionic strength, and the composition of the hydrogel matrix, one can control degradation kinetics, the degree of uptake of a particular pharmacologically active agent, and the overall timed release profile.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.