3-demethylmevalonic acid derivatives, and pharmaceutical products based on these compounds

US4925852A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Kurt Kesseler · Bad Soden am Taunus, DE
• Gerhard Beck · Frankfurt am Main, DE
• Wilhelm Bartmann
• Ernold Granzer · Kelkheim, DE

Key dates

• Filing date: Jul 8, 1988
• Grant date: May 15, 1990
• Expiry date: Jul 8, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-Demethylmevalonic acid derivatives of the formula I (.delta.-lactone) and II (corresponding dihydroxy carboxylic acid derivative) ##STR1## in which A--B, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the indicated meanings, a process for the preparation of these compounds, their use as medicaments, and pharmaceutical products, are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.