Process for preparing 1-hydroxyalkyl-2-methyl-5-nitroimidazoles
US4925951A · kind A · utility
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Key dates
| Filing date | Jan 13, 1989 |
| Grant date | May 15, 1990 |
| Priority date | — |
| Expiry date | Jan 13, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/94
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: ##STR1## which comprises reacting a sulphite or diacetate of an alkylenediol of formula: EQU HO-(CH.sub.2).sub.n -OH (II) in the presence of a strong acid (sulphuric acid) with an imidazole derivative of formula: ##STR2## followed by hydrolizing or alcoholizing the product obtained. In the formulae (I) and (III), R denotes hydrogen or hydrocarbon. In the formulae (I) and (II), n is 2 or 3. In the formula (III), X denotes hydrogen or a radical which can be removed by hydrolysis or alcoholysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.