Dissolution of gas in a fluorocarbon liquid
US4927623A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 4, 1988 |
| Grant date | May 22, 1990 |
| Priority date | — |
| Expiry date | Jan 4, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biocompatible fluorocarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen. A method of preparing biocompatible fluorocarbon emulsions includes preparing a mixture of an emulsifying agent, osmotic agent, buffering agent, aqueous phase and fluorocarbon, forcing the mixture under high pressure into a cavity, against a surface and around a lip to cause turbulence and possibly cavitation to form high fluorocarbon concentration emulsions that are stable through heat sterilization; and, even when oxygenated, maintain substantially stable partial press…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.