Efomycin G and it's use as yield promoter in animals

US4927810A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Klaus Frobel · Wuppertal, DE
• Hartwig Muller · Velbert, DE
• Erwin Bischoff · Wuppertal, DE
• Olga Salcher · Wuppertal, DE
• Anno de Jong · Wuppertal, DE
• Friedrich Berschauer · Wuppertal, DE
• Martin Scheer · Wuppertal, DE

Key dates

• Filing date: Mar 6, 1987
• Grant date: May 22, 1990
• Expiry date: Mar 6, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/886
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An animal growth promoter, efomycin G, is obtained by culturing Streptomycetes strain BS 1261. Efomycin G has the following properties: PA0 (a) The empirical formula: C.sub.53 H.sub.86 O.sub.18 PA0 (b) The mass spectrum (fast atom bombardment) Molecular weight+Na.sup.+ : 1033 PA0 (c) The .sup.1 H-nuclear magnetic resonance spectrum, stated in parts per million, shown in FIG. 1. PA0 (d) The .sup.13 C-nuclear magnetic resonance spectrum, stated in parts per million shown in FIG. 2, with chemical shifts of the CC-NMR signals as follows: ______________________________________ 170.0 77.9 65.9 32.9 7.0 145.4 73.4 48.5 19.4 144.7 71.2 43.6 19.1 131.9 70.6 41.9 16.8 121.1 70.1 41.1 16.7 99.6 69.9 38.8 15.1 99.5 66.9 38.5 13.4 93.6 66.5 36.2 9.0 93.3 66.4 33.0 8.9 ______________________________________ (ppm values are relative to tetramethylsilane at 0 ppm) PA0 (e) A UV absorption maximum at 251-254 nm in methanolic solution PA0 (f) The structure according to FIG. 3.