1,3,4-thiadiazoles

US4927822A · kind A · utility

Assignee

• Fisons plc · GB

Inventors

• Roger Brown · Coalville, GB
• John Dixon · Hudson, US
• David Robinson · Shepshed, GB

Key dates

• Filing date: Aug 27, 1986
• Grant date: May 22, 1990
• Expiry date: Aug 27, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are described compounds of formula I, ##STR1## in which Y is S, O or NR.sub.9, PA1 n is 0 or 1, PA1 R.sub.9 is hydrogen or alkyl C 1 to 10, PA1 R.sub.3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10, CF.sub.3, SR.sub.10, a 5 or 6 membered heterocyclic group containing one or more S, O or N atoms, NR.sub.4 R.sub.5, phenyl or phenylalkyl C7 to 12, the phenyl, phenylalkyl and heterocyclic groups optionally being fused to a further phenyl group, the heterocyclic group and any phenyl group optionally being substituted by alkyl C 1 to 6, halogen, alkoxy C 1 to 6, nitro, nitrile, CF.sub.3, SR.sub.6, NR.sub.7 R.sub.11 or hydroxy, PA1 R.sub.6, R.sub.7 and R.sub.11, which may be the same or different, are each hydrogen or alkyl C 1 to 10, PA1 R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen, alkyl C 1 to 10 or phenyl, PA1 R.sub.10 is alkyl C 1 to 10, PA1 X.sub.1 is S or O, and PA1 A is a chain comprising from 2-16 atoms, which chain carries an O or S containing substitutent at a position 2-6 atoms away from the group C=X.sub.1, PA1 and pharmaceutically acceptable salts, esters and amides thereof, p1 there are also described method of making the compounds an…