Process for the preparation of oxiranes

US4929735A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Wolf Reiser · Wuppertal, DE
• Peter Feyen · Mettmann, DE

Key dates

• Filing date: Apr 22, 1988
• Grant date: May 29, 1990
• Expiry date: Apr 22, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of an oxirane of the formula ##STR1## in which X is 4-chlorobenzyl, 4-phenylphenoxy or 1H-(1,2,4)-triazolyl, comprising reacting dimethyl sulphate with an excess of dimethyl sulphide thereby to form trimethylsulphonium methyl-sulphate of the formula EQU (CH.sub.3).sub.3 S.sym.CH.sub.3 SO.sub.4 .crclbar., and without prior isolation reacting the trimethylsulphonium methyl-sulphate with a keytone of the formula ##STR2## in the presence of solid potassium hydroxide or sodium hydroxide in dimethyl sulphide at a temperature between 0.degree. C. and 50.degree. C.