Process for making an optically active mixture of an N-acyl-amino acid or ester containing at least two chiral centers
US4929755A · kind A · utility
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8Claims
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Key dates
| Filing date | Dec 19, 1986 |
| Grant date | May 29, 1990 |
| Priority date | — |
| Expiry date | Dec 19, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C231/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In the process of hydrocarboxylating an .alpha.-enamide with CO and H.sub.2 O or an organic hydroxyl compound to produce an N-acyl-.alpha.-amino acid or ester, respectively, the improvement comprising using as the .alpha.-enamide reactant, an .alpha.-enamide which has a chiral center that is essentially all L or D, thereby producing a reaction mixture containing diastereomeric N-acyl-.alpha.-amino acids or esters having two chiral centers, said mixture having essentially no enantiomeric pairs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.