Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US4931287A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1988 |
| Grant date | Jun 5, 1990 |
| Priority date | — |
| Expiry date | Jun 14, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains", can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.