Process for stabilizing kinase

US4931392A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Helmut Rehner · Weilheim, DE
• Knut Bartl · Weilheim in Oberbayern, DE
• Peter Stegmuller · Augsburg, DE
• Wilhelm Tischer · Peißenberg, DE
• Sibylle Rollinger · Weilheim, DE

Key dates

• Filing date: May 15, 1989
• Grant date: Jun 5, 1990
• Expiry date: May 15, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/96
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides a process for stabilizing creatine kinase by disulphide modification, wherein creatine kinase is reacted in any desired sequence PA0 (a) with a molar excess of disulphide and/or thiosulphonate and PA0 (b) with a molar excess of water-soluble carbohydrate as carrier.