Bis(indolyl)ethylene compounds

US4931567A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hubertus Psaar · Leverkusen, DE
• Horst Berneth · Leverkusen, DE

Key dates

• Filing date: Sep 19, 1989
• Grant date: Jun 5, 1990
• Expiry date: Sep 19, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Bis(indolyl)ethylenes of the formula ##STR1## wherein R.sub.1 denotes hydrogen, alkyl, aralkyl or aryl, PA1 R.sub.2 denotes hydrogen, alkyl or aryl, PA1 R.sub.3 denotes hydrogen, alkyl, alkenyl, COOH or aryl and PA1 R.sub.4 denotes hydrogen, alkyl, alkoxy, cycloalkoxy or halogen, and these substituents, in turn, can carry non-ionic radicals or a carboxyl group, are obtained by reaction of indoles of the formula ##STR2## with carboxylic acids of the formula EQU R.sub.3 --CH.sub.2 --COOH (III) their chlorides, esters, for example alkyl esters, or anhydrides in the presence of phosphorus oxychloride.