Process for the continuous production of 2-phosphone-butane-1,2,4-tricarboxylic acid and alkali metal salts thereof

US4931586A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Roland Kleinstuck · Bensberg, DE
• Cornelia Lensch · Wermelskirchen, DE
• Michael Immenkeppel · Bonn, DE
• Hans-Dieter Block · Cologne, DE
• Herbert Odenbach · Leverkusen, DE

Key dates

• Filing date: Aug 16, 1989
• Grant date: Jun 5, 1990
• Expiry date: Aug 16, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/3808
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to an improved process for the continuous production of 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC) and alkali metal salts thereof, in which dialkylphosphite, and ethene-1,2-dicarboxylic acid dialkyl ester, are reacted in the presence of a basic catalyst to form phosphonosuccinic acid tetraalkyl ester, the ester thus obtained is directly reacted with alkyl-acrylate, in the presence of an alkaline catalyst and the reaction product thus obtained is directly hydrolyzed to PBTC or alkali metal salts thereof.