Process for forming liposomes
US4933121A · kind A · utility
116Cited by
6References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 25, 1988 |
| Grant date | Jun 12, 1990 |
| Priority date | — |
| Expiry date | Jul 25, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.