Multiple monolayers of polymeric linkages on a solid phase for immobilizing macromolecules
US4933285A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 21, 1988 |
| Grant date | Jun 12, 1990 |
| Priority date | — |
| Expiry date | Dec 21, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
The present invention provides a process for building an immobilized structure comprising multiple monolayers of effective sequential polymeric linkages. The multiple monolayers are built, monolayer by monolayer, from the surface of a solid phase, by an alternating reaction sequence conducted with multifunctional reagents. The process provides the capability of building numerous immobilized multiple monolayer structures wherein the length of each structure extending from a solid phase is substantially the same. Structures comprising multiple monolayers of polymeric linkages are useful for many purposes, as for example, immobilizing macromolecules or other biomolecules and the like to produce chemical or biochemical sensors. Other uses extend to molecular electronic applications, such as the production of molecular conductive wires and molecular circuitry. In a preferred embodiment, carbonyldiimidazole and phenylenediamine are the multifunctional reagents and multiple monolayers of phenylurethane linkages are produced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.