Isomer-directed process for producing asymmetric ketones using catalytic Claisen rearrangement of allylic ethers, intermediates, and uses of products and intermediates of process in perfumery
US4933320A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 16, 1986 |
| Grant date | Jun 12, 1990 |
| Priority date | — |
| Expiry date | May 16, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described is an isomer-directed process for producing asymmetric ketones defined according to the generic structure: ##STR1## wherein one of Z.sub.1 or Z.sub.2 is the moiety: ##STR2## and the other of Z.sub.1 or Z.sub.2 is hydrogen; wherein R.sub.11 and R.sub.21 represent hydrogen or the same or different alkyl or alkenyl with the proviso that R.sub.11 and R.sub.21 are not both hydrogen or wherein R.sub.11 and R.sub.21 taken together: PA1 (i) complete a cycloalkyl, cycloalkenyl, bicycloalkyl, mono or polyalkyl cycloalkyl or mono or polyalkyl cycloalkenyl ring, or PA1 (ii) represent alkylidene, cycloalkenyl alkylidene, aralkylidene, mono or polyalkyl cycloalkenyl alkylidene or mono or polyalkyl aralkylidene; and wherein R.sub.6, R.sub.7 and R.sub.8 are the same or different and each represents hydrogen or methyl, using a catalytic Claisen rearrangement of allylic ethers previously formed by reacting substituted or unsubstituted allylic alcohols defined according to the structure: ##STR3## with dialkyl ketals defined according to the structure: ##STR4## wherein R.sub.4 and R.sub.5 represent the same or different C.sub.1 -C.sub.4 alkyl. Also described are compounds and processes for u…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.