Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity
US4933326A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 1988 |
| Grant date | Jun 12, 1990 |
| Priority date | — |
| Expiry date | Sep 21, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Heparin fractions which are a mixture of oligosaccharides containing 6-12 monosaccharides are described. The oligosaccharides contain reducing end groups composed of iduronic acid 2-sulfate or glucosamine N, 6-disulfate. The end group monosaccharides contain the reducing anomeric carbons. The SO.sub.3.sup.- /COO.sup.- ratio is essentially the same as in heparin. The method of preparation is a depolymerization initiated by free radicals. One fraction is a heparin fragment with a molecular weight (MWw) of 2,100 daltons (+10%). The compound contains 6-8 monosaccharides, has the same SO.sub.3.sup.- /COO.sup.- ratio as the parent heparin and has platelet anti-aggregating activity, arterial and venous antithrombotic action, fibrinolytic and antiatherosclerotic activity. It exhibits poor anti factor Xa activity and no anticoagulant action.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.