Isoxazole-.beta.-carboline derivatives

US4933345A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Huth · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Ralph Rohde · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Dieter Seidelmann · Berlin, DE
• Herbert Schneider · Berlin, DE
• David N. Stephens · Berlin, DE
• John Bondo Hansen · Avenue Madeleine, DK
• Mogens Engelstoft
• Preben Olsen · Copenhagen, DK

Key dates

• Filing date: Aug 29, 1988
• Grant date: Jun 12, 1990
• Expiry date: Aug 29, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

.beta.-Carbolines of general Formula I ##STR1## wherein Y represents the residue ##STR2## and R.sup.a and R.sup.b, being identical or different, mean respectively hydrogen, C.sub.1-6 -alkoxy, phenyl, C.sub.3-7 -cyclo-alkyl, optionally substituted C.sub.1-6 -alkyl or C.sub.1-6 -alkoxycarbonyl, and R.sup.c and R.sup.d, being identical or different, mean respectively hydrogen or C.sub.1-6 -alkyl or jointly a linkage, and PA1 R.sup.4 is hydrogen, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy-C.sub.1-6 -alkyl and PA1 R.sup.5 is hydrogen, halogen, OR.sup.6, NR.sup.7 R.sup.8 or CH R.sup.9 R.sup.10 wherein R.sup.6 means C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or an optionally substituted aralkyl, aryl or hetaryl residue, R.sup.7 and R.sup.8, being identical or different, represent hydrogen, C.sub.1-6 -alkyl, C.sub.3-6 -alkenyl, or jointly with the nitrogen atom a saturated heterocyclic five- or six-membered ring which optionally contains a further hetero atom, R.sup.9 means hydrogen or C.sub.1-6 -alkyl, R.sup.10 means hydrogen, C.sub.1-6 -alkyl, OR.sup.11 or NR.sup.12 R.sup.13 wherein R.sup.11 means C.sub.1-6 -alkyl, R.sup.12 and R.sup.13 are identical or different and mean hydrogen, C.sub.1-6 -al…