Preparation of phenyl-substituted epoxides

US4933477A · kind A · utility

Assignee

• BASF SE

Inventors

• Norbert Goetz
• Hans-Gert Recker · Ludwigshafen, DE
• Hubert Smuda · Heidelberg, DE

Key dates

• Filing date: Aug 25, 1988
• Grant date: Jun 12, 1990
• Expiry date: Aug 25, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenyl-substituted epoxides of the formula ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, alkyl, alkenyl, phenyl, halogen, nitro, alkoxy, haloalkyl, phenoxy or phenylsulfonyl, are prepared by reducing a haloacetophenone to a halohydrin and reacting the halohydrin with an alkali metal hydroxide by a process in which the reduction with the alkali metal borohydride and the reaction are carried out in aqueous organic solution, or the cyclization of a halohydrin with an alkali metal hydroxide is carried out in an organic liquid.