Antibiotic A 40926 complex and its pure factors PA, PB, A, B and B.sub.0

US4935238A · kind A · utility

Assignee

• Gruppo Lepetit S.p.A. · IT

Inventors

• Enrico Selva · Gropello Cairoli, IT
• Grazia Beretta · Milano, IT
• Luciano Gastaldo · Pogliano Milanese, IT
• Angelo Borghi · Milano, IT
• Beth P. Goldstein · Milano, IT
• Giovanni Cassani · Pavia, IT
• Vittorio Arioli · Cantù, IT
• Francesco Parenti

Key dates

• Filing date: Oct 9, 1985
• Grant date: Jun 19, 1990
• Expiry date: Oct 9, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/03
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention concerns a new antibiotic substance arbitrarily denominated antibiotic A 40926 complex and its factors antibiotic A 40926 factor A, antibiotic A 40926 factor B, antibiotic A 40926 factor B.sub.0, antibiotic A 40926 factor PA and antibiotic A 40926 factor PB, a process for producing them by culturing the new strain Actinomadura sp. ATCC 39727 or an A 40926 producing variant or mutant thereof and the use of these new antibiotic substances in the treatment of infectious diseases involving microorganisms susceptible to them. The antibiotic substances of the invention are glycopeptidic substances belonging to the vancomycin class of antibiotics which have binding capacity to Acyl-D-Alanyl-D-Alanine.