Phosphorus containing peptides, pharmaceutical compositions and method of treating collagenolytic conditions
US4935404A · kind A · utility
11Cited by
7References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 14, 1988 |
| Grant date | Jun 19, 1990 |
| Priority date | — |
| Expiry date | Nov 14, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the formula (I), a process for their preparation and their use as collagenase inhibitors are described: ##STR1## in which R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen or alkyl; R.sub.3 is C.sub.3-6 alkyl; R.sub.4 is hydrogen, alkyl, --CH.sub.2 --Z where Z is optionally substituted phenyl or heteroaryl, or R.sub.4 is a group ##STR2## where R.sub.8 is hydrogen, alkyl or --CH.sub.2 --Ph where Ph is optionally substituted phenyl, and R.sub.9 is hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.