Disubstituted pyrroles

US4937255A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Walter Hubsch · Wuppertal, DE
• Rolf Angerbauer · Wuppertal, DE
• Peter Fey · Wuppertal, DE
• Hilmar Bischoff · Wuppertal, DE
• Dieter Petzinna · Mülheim an der Ruhr, DE
• Delf Schmidt · Wuppertal, DE
• Gunter Thomas · Arese, IT

Key dates

• Filing date: Mar 16, 1989
• Grant date: Jun 26, 1990
• Expiry date: Mar 16, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R.sup.1 is aryl or heteroaryl, PA1 R.sup.2 is cycloalkyl or optionally substituted alkyl, PA1 R.sup.3 is hydrogen or cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl, PA1 X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, PA1 A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, a cation or alkyl, aryl or aralkyl.