Flavanone derivatives

US4937257A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Helmut Wahlig · Darmstadt, DE
• Elvira Dingeldein · Darmstadt, DE

Key dates

• Filing date: Aug 28, 1985
• Grant date: Jun 26, 1990
• Expiry date: Aug 28, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New flavanone derivatives of the formula I ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO.sub.2 and/or substituted by a methylenedioxy group, and the alkyl, alkoxy and acyl groups each have 1-7 C atoms, but wherein the HO group is only in the 6-position if at least one of the radicals Ar.sup.1 and Ar.sup.2 is substituted phenyl, and the phosphoric acid esters thereof and the salts of these compounds display antiallergic effects. Salts of the I-phosphoric acid esters with aminoglycoside antibiotics are outstandingly stable and possess advantageous kinetics of liberation.