Macrophage stimulation by homologs or analogs of quadrol

US4937269A · kind A · utility

Assignee

• THE UNIVERSITY OF AKRON · US

Inventors

• Daniel J. Smith · Manalapan, US
• Sanjay Patel · Palo Alto, US
• Edwin C. Rowland · Athens, US

Key dates

• Filing date: Oct 14, 1988
• Grant date: Jun 26, 1990
• Expiry date: Oct 14, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are substituted alkyl (C.sub.2 -C.sub.6) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R.sub.3 and R.sub.4 are alkyl or substituted alkyl (C.sub.1 -C.sub.6), and n=2 to about 6. Preferably R.sub.1 through R.sub.4 are the same and are 2-hydroxyalkyl.