Substituted heterocyclic compounds and the pharmacologically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them

US4937337A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Herbert Leinert · Heppenheim, DE
• Christos Tsaklakidis · Weinheim, DE
• Peter C. Freund · Ketsch, DE

Key dates

• Filing date: Mar 10, 1989
• Grant date: Jun 26, 1990
• Expiry date: Mar 10, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of the general formula: ##STR1## wherein R.sub.1 is a straight-chained or branched C.sub.1 -C.sub.12 -alkyl radical which can be substituted by a phenyl, naphthyl or C.sub.3 -C.sub.7 -cycloalkyl radical, a straight-chained or branched C.sub.2 -C.sub.12 -alkenyl radical which can be substituted by a C.sub.3 -C.sub.7 -cycloalkyl, phenyl or naphthyl radical, a C.sub.3 -C.sub.7 -cycloalkyl radical or an unsubstituted or mono- or polysubstituted mono- or bicyclic aromatic radical, in which the substituents can be halogen atoms, carboxyl groups or C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkoxycarbonyl radicals, R.sub.2 and R.sub.3, which can be the same or different, are straight-chained, branched, saturated or unsaturated C.sub.1 -C.sub.6 -alkyl radicals or, together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring which can contain further heteroatoms and can possibly be substituted by a C.sub.1 -C.sub.6 -alkyl radical, one or more C.sub.1 -C.sub.6 -alkoxy radicals, one or more hydroxyl groups or by an oxygen atom, X is a methylene radical, an oxygen or sulphur atom, a sulphox…