Patent · US Expired

Process for the preparation of D-(+)-biotin

US4937351A · kind A · utility

2Cited by

1References

2Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Eike Poetsch · Mühltal, DE
Michael Casutt · Pfungstadt, DE

Key dates

Filing date	Oct 17, 1989
Grant date	Jun 26, 1990
Priority date	—
Expiry date	Oct 17, 2009

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

D-(+)-biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in Patent Claim 1, in a simple, sterospecific manner. Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.