Lipophile derivatives of muramylpeptides having properties of activating macrophages and compositions containing them

US4939122A · kind A · utility

Assignee

• Agence Nationale de Valorisation de la Recherche · FR

Inventors

• Nigel C. Phillips · Rue du Bois des Loges, CA
• Francoise Audibert · Neuilly-sur-Seine, FR
• Jean-Marie Bernard · Brignais, FR
• Louis Chedid · Paris, FR
• Pierre Lefrancier · Les Ulis, FR
• Michel Level · Paris, FR
• Monique Parant · Paris, FR

Key dates

• Filing date: Jun 9, 1988
• Grant date: Jul 3, 1990
• Expiry date: Jun 9, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group containing two atoms contiguous with one another to each of which is attached a lipophile chain comprising from 8 to 100 carbon atoms, preferably from 14 to 24 carbon atoms. The derivatives according to the invention are endowed with remarkable stimulating properties with respect to the activation of macrophages, of which they amplify the tumoricidal properties.