New anellated indole derivatives

US4939136A · kind A · utility

Assignee

• Duphar International Research B.V. · NL

Inventors

• Hans H. Haeck · Weesp, NL
• Derk Hamminga · Weesp, NL
• Ineke van Wijngaarden · Weesp, NL
• Wouter Wouters · Weesp, NL

Key dates

• Filing date: Jun 24, 1988
• Grant date: Jul 3, 1990
• Expiry date: Jun 24, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new anellated indole derivatives of general formula 2, ##STR1## wherein p1 R.sub.0 is alkyl or alkoxy having 1-4 C-atoms, phenylalkoxy having 1-3 C-atoms in the alkoxy group, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or a group R.sub.7 S(O).sub.p, wherein R.sub.7 is alkyl having 1-4 C-atoms and p has the value 0, 1 or 2, or R.sub.0 is a group R.sub.8 R.sub.9 N, R.sub.8 R.sub.9 N--CO--CH.sub.2 -- or R.sub.8 R.sub.9 --N--CO wherein R.sub.8 and R.sub.9 are hydrogen or alkyl having 1-4 C-atoms or R.sub.8 R.sub.9 N forms a saturated 5- or 6-membered ring and n has the value 0, 1 or 2, Z together with the carbon atom and nitrogen atom to which Z is bound and the intermediate carbon atom, forms a heterocyclic group consisting of 5-8 ring atoms, in which, in addition to the nitrogen atom already present, a --CO--group or a second hetero atom from the group N, O, S, S-O or SO.sub.2 may be present, which ring may be substituted with 1-3 alkyl groups having 1-4 C-atoms, a phenyl group or a spiroalkyl group (C.sub.2 -C.sub.5), or which ring may be anellated with a saturated or non-saturated carbocyclic or heterocyclic ring which consists…