Antihypertensive N-piperazinylalkanoylanilides

US4940711A · kind A · utility

Assignee

• Recordati S.A. Chemical and Pharmaceutical Company · CH

Inventors

• Dante Nardi · Milano, IT
• Amedeo Leonardi · Milano, IT
• Alberto Catto · Milano, IT
• Gabriele Graziani · Arese, IT

Key dates

• Filing date: Jun 30, 1989
• Grant date: Jul 10, 1990
• Expiry date: Jun 30, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/66
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N-piperazinylalkanoylanilides of the formula ##STR1## wherein n is 0, 1 or 2, each of R and R.sub.1 is H or alkyl, and each of R.sub.2, R.sub.3 and R.sub.4 is H, halogen, alkyl, hydroxyalkyl, alkoxy, aralkoxy, alkylthio, aralkylthio, alkylsulphonyl, alkylsulphenyl, NO.sub.2, NH.sub.2, alkylamino, acylamino, ureido, alkylureido, alkylsulphonylamino, CF.sub.3, acyl, CN, COOH, alkoxycarbonyl, NH.sub.2 CO, SO.sub.3 H, guanidinosulphonyl, carbamoyloxy, OH, acyloxy, alkylsulphonyloxy, alkylenedioxy or SO.sub.2 NR.sub.5 R.sub.6 wherein each of R.sub.5 and R.sub.6 is H, alkyl, aryl or acyl and their pharmaceutically acceptable acid addition salts, are antihypertensive agents.