2-amino-tetrahydro-isoquinolene derivatives and a process for the preparation thereof and pharmaceutical compositions containing same
US4940716A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1988 |
| Grant date | Jul 10, 1990 |
| Priority date | — |
| Expiry date | Dec 29, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) ##STR1## wherein R stands for hydrogen or chlorine, PA1 R.sup.1 and R.sup.2 are hydrogen, methoxy or ethoxy, and PA1 R.sup.3 and R.sup.4 are hydrogen or methyl, and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the Formula (II) ##STR2## with a carboxylic acid derivative of the Formula (III) ##STR3## wherein x stands for chlorine, --OH, --OCH.sub.2 CN, --OCH.sub.3, --OC.sub.2 H.sub.5, --OCOOCH.sub.3 or --OCOOC.sub.2 H.sub.5 PA1 R.sup.5 and R.sup.6 stand for hydrogen or together from CHN(CH.sub.3).sub.2 and in case of the Formula (Ia) ##STR4## splitting off the protective group in alkaline medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.