Novel HMG-CoA reductase inhibitors

US4940727A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Edward S. Inamine · Rahway, US
• Otto D. Hensens · Red Bank, US
• David Renwick Houck · Cary, US
• Ta J. Lee · Lansdale, US
• Robert L. Smith · Lansdale, US
• Wasyl Halczenko · Lansdale, US
• George D. Hartman · Lansdale, US
• Gerald E. Stokker · Gwynedd Valley, US

Key dates

• Filing date: Oct 6, 1988
• Grant date: Jul 10, 1990
• Expiry date: Oct 6, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/365
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as anti-hypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1##