5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2-amino-6H-1,3,4-thiadiazines

US4940790A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Thorwart · Hochheim, DE
• Ulrich Gebert · Königstein, DE
• Rudolf Schleyerbach · Hofheim, DE
• Robert R. Bartlett · Darmstadt, DE

Key dates

• Filing date: Jan 28, 1988
• Grant date: Jul 10, 1990
• Expiry date: Jan 28, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel 5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2-amino-6H-1,3,4-thiadiazines of the general formula I ##STR1## in which R.sup.1 =C.sub.1 -C.sub.4 -alkyl, PA0 R.sup.2 =H or C.sub.1 -C.sub.3 -alkyl PA0 R.sup.3 and R.sup.4 =independently of one another, optionally substituted and optionally O- or S-interrupted alkyl, alkenyl or alkynyl groups, it being possible for one of the two radicals to also be H, PA0 or R.sup.3 +R.sup.4 together with the nitrogen atom to which they are bound, may denote an optionally substituted 4- to 7-membered ring which optionally contains a further heteroatom (O, S or N), and the physiologically acceptable acid-addition salts thereof. The compounds are primarily suitable for prevention and treatment of inflammatory--in particular inflammatory rheumatic--disorders and/or pain.