Process for synthesis of 1R,2R,5R-2-hydroxy-6-oxo-7-oxabicyclo[3.2.1]-octane
US4940803A · kind A · utility
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Key dates
| Filing date | May 23, 1988 |
| Grant date | Jul 10, 1990 |
| Priority date | — |
| Expiry date | May 23, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for the synthesis of hydroxy lactone 3, being 1R, 2R, 5R-2-hydroxy-6-oxo-7-oxabicyclo[3.2.1]-octane, in optically pure form, which is useful as an intermediate in the synthesis of the C.sub.20 -C.sub.34 chain of the macrolide structure for the immunosuppressant FK-506. This compound is also useful as a precursor for producing an ultraviolet radiation absorber.
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